Je fakt, že v modernom svete sa nemôžeme vyhnúť stálemu účinku toxických látok. Vzhľadom na ich značný potenciál poškodzovať naše zdravie je dôležité, aby sme podnikli kroky na zmiernenie ich nežiaduceho vplyvu, a to konzumáciou protizápalovej stravy, bohatej na živiny, pravidelným cvičením, dostatkom spánku, znížením nášho kontaktu s enviromentálnymi toxínmi, atď.
Ukázalo sa však, že to nestačí. Je potrebné užívať i ďalšie živiny, ktoré sú schopné regulovať vnútorné detoxikačné systémy nášho tela, zlepšiť stav hladiny antioxidačného enzýmu glutatiónu a predovšetkým aktivovať super regulačný gén Nrf2. To všetko, a ešte oveľa viac, dokáže fytochemikália sulforafan, ktorého najviac obsahuje brokolica. Sám „jednou ranou“ rieši neuveriteľnú paletu zdravotných problémov. Mnohí pacienti, ktorí majú s užívaním sulforafanu osobné skúsenosti, ho označujú za zázračný liek. Väčšina ľudí zaznamená účinky sulforafanu do dvoch dní až do dvoch týždňov. Jeden z hlavných účinkov, ktorý si ľudia zvyknú okamžite všimnúť, je citeľné zníženie chronického zápalu alebo bolesti. A to sa dlhším užívaním sulforafanu ešte výraznejšie zlepšuje, keď sa regulačný gén Nrf2 stáva pod jeho vplyvom v závislosti od zdravotného stavu jednotlivých orgánov nášho tela aktívnejším. Sulforafan je stále horúcou témou a každá nová štúdia, ktorá vyjde, dokazuje prečo. Čím viac vedci túto molekulu skúmajú, tým viac sú ohromení jej potenciálom predchádzať chorobám, zvrátiť ich priebeh a dramaticky zlepšiť naše zdravie a pohodu. Konštatujú, že nie je to ,samozrejme, zázračný liek, ale je to jedna z najsľubnejších terapeutických živín, s ktorými sa doteraz stretli.
Vedci zistili, že sila sulforafanu spočíva v mnohostrannosti jeho účinku s množstvom výhod. Podporuje imunitné funkcie, napríklad tým, že zvyšuje tvorbou a lytickú aktivitu NK buniek, blokuje zápaly tým, že potláča NF-kB kľúčový regulátor zápalu, čím sa zabráni tvorbe zápalových enzýmov (COX-2 a iNOS). Podporuje detoxikáciu, najmä dôležitú fázu dva, ktorá je kritická. Tým sa odlišuje od väčšiny detoxikačných výživových doplnkov, ako je napríklad vitamín C, ktorý podporuje len prvú fázu a preto nie je schopný chrániť nás pred všetkými mutagénnymi a karcinogénnymi látkami. Sulforafan to dokáže tým, že aktivuje NQO1, čo je enzým fázy dva, nevyhnutný pri zneškodnení mnohých toxínov, oxidovaných živín a rôznych škodlivých metabolitov.
Sulforafan - ako nepriamy superantioxidant - nás chráni pred oxidačným stresom, ktorý je súčasťou takmer všetkých chronických ochorení a tiež procesu starnutia. Má protirakovinové účinky tým, že prostredníctvom Nrf2 „zapína“ gény, ktoré bránia vzniku rakoviny a „vypína“ tie, ktoré pomáhajú pri jej vzniku a rozširovaní. Má priaznivé účinky pri srdcovocievnych ochoreniach tým, že podporuje a zvyšuje tvorbu srdce ochraňujúceho proteínu tioredoxínu, ktorý zohráva významnú úlohu pri ochrane srdca pred kyslíkovými radikálmi. Indukuje činnosť antioxidačných génov NrF2 produkujúcich proteíny, ktoré chránia výstelkové bunky tepien pred oxidačným stresom, a tak zabraňujú ateroskleróze. Ďalej má antivírusové a antibakteriálne účinky (vrátane Helicobacter pylori). Chráni a obnovuje funkciu mozgu tým, že ľahko prechádza cez krvno-mozgovú bariéru, čo mu umožňuje vyvolať antidepresívne, protiúzkostné účinky a mnoho ďalších zdravotných výhod. Ako je možné, že sulforafan má také široké spektrum účinku? Odpoveď našli vedci, keď zistili, že primárnym mechanizmom ochranného a liečebného potenciálu sulforafanu je indukcia super regulačného génu Nrf2.
Je najúčinnejší aktivátor Nrf2 vďaka tomu, že je malou molekulou schopnou zlučovať sa s tukmi. Má absolútnu biologickú dostupnosť okolo 80%, kým ostatné známe aktivátory (resveratrol, symilarin, kurkumín) sú veľké hydrofilné molekuly a ich biologická dostupnosť je len 1 – 8%.
Každému, kto mal rakovinu, má v rodinnej anamnéze rakovinu alebo kto chce byť proaktívny pri znižovaní rizika rakoviny. A všetkým, ktorí majú zápalovú alebo autoimunitnú chorobu, ako je artritída, syndróm dráždivého čreva, nadváha, obezita, vysoká hladina cukru v krvi, inzulínová rezistencia, alebo majú akýkoľvek druh chronického zápalu alebo bolesti. Môže to byť dokonca akútne zranenie chrbta alebo chronické zranenie, ktoré sa v nás „rozhorí“. Pacientom s mozgovou hmlou, problémami s pamäťou, problémami so zapamätaním slov alebo inými kognitívnymi problémami, osobám s akýmkoľvek druhom depresie, úzkosti a trpiacim na vážnejšie duševné choroby ako napríklad schizofrénia. Pacientom s neurodegeneratívnymi stavmi, ako je demencia, Alzheimerova choroba, Parkinsonova choroba, epilepsia atď. Aj deťom alebo dospelým s poruchou pozornosti/hyperaktivity, poruchami autistického spektra alebo inými poruchami správania. A nakoniec všetkým nad 60+, ktorí to myslia s dlhovekosťou a zdravým vážne.
Ešte nie je určené dávkovanie, ale podľa doterajších skúseností:
Pri prevencii nepretržite aspoň 4 mesiace 1 dvojzložkovú kapsulu (glukorafanín+myrozináza) denne spolu s jedlom, potom urobiť 2 mesiace prestávku.
Pri liečbe nepretržite užívať 5 - 6 mesiacov 2 dvojzložkové kapsule denne (ráno a večer), potom prerušiť na mesiac (aj na dva, podľa stavu choroby).
Prof. RNDr. Katarína Horáková, DrSc.
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